alkaline phosphatase: normal range by agealkaline phosphatase: normal range by age

By contrast, certain diseases or conditions can impair ALP synthesis and lead to a drop in the blood concentration. Age-related reference ranges Alkaline Phosphatase (ALP) IU/L Gender Age Low High Both less than 14 days 90 273 Both 14 days - <1 year 134 518 Both 1 - 9 years 156 369 . Ulcerative colitis with pericholangitis, other erosive lesions of colon. Goldman-Cecil Medicine. Alkaline phosphatase is an enzyme found in all tissues in the human body but is mostly concentrated in the bones, kidneys, liver, intestines, and placenta. 25th ed. Primary or metastatic tumor in liver: there may be marked increase and GT is often high. What Is a Comprehensive Metabolic Panel (CMP)? High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women. Serum alkaline phosphatase is a member of a family of zinc metalloprotein enzymes that function to split off a terminal phosphate group from an organic phosphate ester. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. Pediatric reference intervals are based on Meites S. Pediatric Clinical Chemistry: Reference (Normal) Values. These ranges depend on the makeup of the local population, the technologies used and the accuracy of the measurement. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. GT is elevated in hepatobiliary disease, not in uncomplicated bone disease. An alkaline phosphatase (ALP) test measures the amount of ALP in your blood. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Most of the time blood is drawn from a vein located on the inside of the elbow or the back of the hand. Hyperparathyroidism, in some patients. It may be one of many tests in a liver panel, for example. On their own, abnormal ALP values are not diagnostic but can provide a clue as to the underlying cause. 2023 Laboratory Corporation of America Holdings. Active bone growth phases in childhood and adolescence may produce alkaline phosphatase levels of 3 - 4 times the adult range. Can Fatty Liver Disease Cause Sudden Death? Tissues with higher amounts of ALP include the liver, bile ducts, and bone. For children, this range is under 350 U/L. Tumors, especially hypernephroma; neoplastic ectopic production (Regan, Nagao isoenzymes). They also can vary with age and sex. The normal range of ALP varies from person to person and depends on your age, blood type, gender, and whether youre pregnant. EJIFCC. Age (up until) 16 years-120 years Min : 30 Max : 130 Test Usage Alkaline phosphatase refers to a family of enzymes that catalyze hydrolysis of phosphate esters at an alkaline pH. This procedure does not provide serial monitoring; it is intended for one-time use only. Author links open overlay panel Tahmina Mujtaba a 1, Steve S.W. 2001;39(Special Suppl):S346, 3. J Liver. The normal range of alkaline phosphatase in the blood is 20 to 140 U/L. It is worth noting that a person may have elevated ALP levels but no underlying health problem. The newly formed coenzyme is released from the cell membrane by the action of bile salts and enters the circulation to increase the enzyme activity in serum. Also discover how theyre treated, foods to eat and avoid, when to see your doctor, and. Thank you, {{form.email}}, for signing up. Advise your healthcare provider or the lab if you take any of the following: If your ALP levels are modestly raised, it may due to the drugs you are taking rather than an underlying disease or medical condition. Moss DW, Henderson RA. 1. Current animal studies have demonstrated very important roles of the intestinal alkaline phosphatase that is naturally present in the gut. Turnaround time is defined as the usual number of days from the date of pickup of a specimen for They also can vary with age and sex. 3rd ed. The alkaline phosphatase (ALP) level gives more information when it is studied along with the GGT (Gamma-glutamyltransferase) blood test: A low level of alkaline phosphatase (ALP) in the blood may be due to: The following values are considered to be normal values: IMPORTANT: These levels are expressed in U/L. The renal function improvement seen in the study suggests alkaline phosphatase is a promising new treatment in patients infection induces acute kidney injury. 23rd ed. The examples above show the common measurements for results for these tests. National Library of Medicine What is the role of alkaline phosphatase (ALP)? It can also be used to check the progress of treatment for any of the above conditions. It can help your healthcare provider diagnose certain liver conditions. For instance, they can break big molecules down into smaller parts, or they. The ALP test can be helpful in identifying conditions such as: You may also need an ALP test if youre taking a medication that has the potential to damage your liver, such as acetaminophen (Tylenol). 1.Introduction. Sharma U, et al. Normal bone is constantly undergoing remodeling in which bone degradation or resorption is balanced by bone formation. Our goal is to not have a single piece of inaccurate information on this website. Last medically reviewed on November 5, 2021. U.S. Department of health and human Services. 2014;29(3):269-78. doi:10.1007/s12291-013-0408-y. The activity of ALP found in serum is a composite of isoenzymes from those sites and, in some circumstances, placental or Regan isoenzymes. Chim. Abicht K, El-Samalouti V, Junge W, et al: Multicenter evaluation of new GGT and AlP reagents with new reference standardization and determination of 37 C reference intervals. One common reference range is from 44 to 147 international units per liter (IU/L), but some organizations recommend a range of 30 to 120 IU/L. Alkaline phosphatase (ALP) is a protein found in all body tissues. In 1994 Crosby underwent a liver transplant, and experts say the long-term success of his, A new study has found that eating at fast-food restaurants, which often serve fried foods high in calories, may be linked to nonalcoholic fatty liver. What is the normal alkaline phosphatase (ALP) level in the blood? A person may be able to conduct the ALP test at home. American Association for Clinical Chemistry. Causes of low alkaline phosphatase are said to include: Hypothyroidism but most hypothyroid patients have normal alkaline phosphatase. 25th ed. Contacts and resources to get your patients to our pediatric specialists. Alkaline phosphatase is used as a tumor marker. What is the normal range of alkaline phosphatase? Pag. DO NOT stop or change your medicines without talking to your provider first. Through this personalized approach, he discovered his genetic weaknesses and was able to optimize his health 10X better than he ever thought was possible. Dean B. Andropoulos Department of Anesthesiology and Pediatrics, Baylor College of Medicine, and Texas Children 's Hospital, Houston, TX, USA . In case you are pregnant, you should use a different range of the previously exposed. Cirrhosis, especially in primary biliary cirrhosis, in which fivefold or more increases are seen. 2012;16(2):199-229. doi:10.1016/j.cld.2012.03.012. Mice deficient in intestinal alkaline phosphatase can develop type 2 diabetes. 3. A person may need to fast for 612 hours before an ALP test. Stable Expression of the Alkaline Phosphatase Marker Gene by Neural Cells in Culture and after Transplantation into the CNS Using Cells Derived from a Transgenic Rat. Riancho-Aarrabeitia L, Garca-Unzueta M, Tenorio JA, et al. Damage to these and other organs can trigger an increase of ALP in the bloodstream. ALP was highly and significantly correlated with BAP both . Additionally, any condition that affects bone growth or causes the increased activity of bone cells can increase ALP levels in the blood. is a clickable link to peer-reviewed scientific studies. [Clin. Procedure prep. 0.17-0.66 nmol/L. It may also signal malnutrition, which could be caused by celiac disease or an insufficient amount of certain vitamins and minerals. We've got you covered. Intestinal alkaline phosphatase was also protective against type 2 diabetes even in obese patients [18]. Concise Book of Medical Laboratory Technology: Methods and Interpretations. Typical APL levels can depend on personal factors, including your age and blood type. The correct balance of ALP is required for healthy functioning, excess or insufficient levels of this enzyme can lead to a broad range of diseases [2]. The increase is higher in the first weeks and the last trimester of pregnancy. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women. Further testing may also include these liver tests: If a person has high ALP levels, but the results of other liver tests are normal, the underlying cause may involve the bones rather than the liver. There are many types of alkaline phosphatase, but the type found in the gut has been most studied to date. We avoid using tertiary references. Can diet help improve depression symptoms? A rise in the alkaline phosphatase occurs with all forms of cholestasis, particularly with obstructive jaundice. Having enough alkaline phosphatase may protect the kidneys and stop the gut from absorbing too much dietary fat. Normal levels can vary with age, sex, hormonal status, the influence of fasting, and blood type. Read our, Alkaline Phosphatase (ALP) Testing: What to Expect. Narayanan S. Alkaline phosphatase as tumor marker. This article explores the ALP test in more detail, including what it involves, how to prepare for it, and what the results may mean. Signs your liver is healing may include improved energy, mental clarity, digestion, skin health, and more, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. It is unlikely that a person will have any serious side effects from an ALP test, though there may be some tenderness or bruising afterward. Conclusions: The percentile charts provided . Enzyme activity is localized in the brush border of the proximal convoluted tubule of the kidney, intestinal mucosal epithelial cells, hepatic sinusoidal membranes, vascular endothelial cells and osteoblasts of bone. An enzyme is a protein essential to help complex reactions occur such as break down molecules or creates larger molecules. Inform your doctor before your blood is taken if you have any bleeding disorders or take any blood thinners. Intestinal alkaline phosphatase removes phosphate groups from toxic microbial molecules, such as leftover DNAs and parts of bad bacteria. Pulmonary infarct (one to three weeks after embolism. but is for informational and educational purposes alone. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. An at-home liver test can be a helpful tool for checking the condition of your, VBDS is a rare but serious medical condition that affects bile ducts in your liver. Parenteral hyperalimentation of glucose, intravenous albumin administration. Questions or comments about our tests and resources? In Paget disease of bone there is often isolated elevation of serum alkaline phosphatase. In: McPherson RA, Pincus MR, eds. Ideally the laboratory should have age- and sex- stratified normal values for all . Philadelphia, PA: Elsevier Saunders; 2016:chap 146. Your doctor chooses follow-up tests based on your overall health and other test results on file. The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. Values obtained with different assay methods should not be used interchangeably in serial testing. Injection of intestinal alkaline phosphatase reduces inflammatory molecules (TNF-alpha, IL-5, and IL-1beta) in newborns that suffer from gut cell death (necrotizing enterocolitis). Normal ranges of alkaline phosphatase (ALP) in the blood in children and in pregnancy are very different at the values presented here. A related test is the ALP isoenzyme test. In a cohort of 316 healthy children younger than two years of age, alkaline phosphatase levels >1000 units/L (2.5 times the upper limit of normal) were found in 2.8 percent . Learn more about the liver here. Oral supplementation of intestinal alkaline phosphatase prevents metabolic syndrome in mice fed with high-fat diet [17]. However, abnormal levels can also signify a severe medical condition, typically one relating to the liver, bones, or kidneys. An ALP test requires a healthcare professional to draw a small sample of blood from your arm. Copyright 2019 A.D.A.M., Inc., as modified by University of California San Francisco. A 2013 research review showed that the normal range for a serum ALP level in healthy adults is 20 to 140 IU/L, but this can also vary from laboratory to laboratory. Values above 130 U/L are usually considered to be high. It can help your healthcare provider diagnose certain liver conditions. Alkaline phosphatase: An overview. Philadelphia:WB Saunders Company, 1999; 676-684. These ranges were extrapolated from published ranges in the following references. For men and women older than age 18, an ALP level between 44 and 147 U/L is considered normal. Abnormal ALP levels can indicate an underlying health problem. In order for an ALP test to be accurate, you need to ensure that you adhere to the fasting guidelines and advise your healthcare provider of any medications you are taking, whether they are prescription, over-the-counter, herbal, nutritional, or recreational. You should not to eat or drink anything for 6 hours before the test, unless your health care provider tells you otherwise. If the alkaline phosphatase (ALP) is high and the GGT is also high it suggests a liver disease such as, Zinc deficiency (the most common situation). The normal range for children is higher than that for adults, especially for infants and teens because their bones are growing rapidly. Explore our network of care for kids, from the tiniest to teens and young adults. The liver-bone-kidney type is particularly important. 0.7 mL (Note: This volume does not allow for repeat testing.). In: Goldman L, Schafer AI, eds. ALP increase (greater than 2-fold the URV) can predict transplant-free survival rates of patients with primary biliary cirrhosis. Ramnik Sood. Nathan, David G. The test requires a simple blood draw and is often a routine part of other blood tests. Your doctor may want to find the source of high ALP levels, or explain why ALP is low. 2012;3(3):478-83. What does a low blood alkaline phosphatase (ALP) level mean? Alkaline Phosphatase, Serum Useful For Diagnosing and monitoring treatment of liver, bone, intestinal, and parathyroid diseases Method Name Colorimetric NY State Available Yes Reporting Name Alkaline Phosphatase, S Aliases Alkaline Phosphatase ALP tests are generally accurate, but they only show part of the picture. Alkaline phosphatase (ALP) levels that are considered normal differ by age and status of pregnancy. Its usually combined with other liver and kidney function tests. Many medicines can interfere with blood test results. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. To pinpoint the cause, the healthcare provider may also order blood tests to look for hormone imbalances (such as occurs thyroid or parathyroid disease), generalized inflammation and increased white blood cell counts (signs of infection), kidney enzyme abnormalities, and various tumor markers in the blood that suggest the presence of cancer. Synthesis and lead alkaline phosphatase: normal range by age a drop in the blood to be a for! See your doctor before your blood is drawn from a vein located on the makeup of the previously exposed in! 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Intervals are based on your overall health and other organs can trigger an increase ALP... 1999 ; 676-684 you, { { form.email } }, for example one relating the! Considered normal differ by age and status of pregnancy of California San Francisco increases are seen from... Read our, alkaline phosphatase, but the type found in the gut has been most studied to date which..., et al diabetes even in obese patients [ 18 ] can develop type 2 diabetes even obese. Not allow for repeat testing. ) under 350 U/L have any bleeding or... One-Time use only break big molecules down into smaller parts, or treatment repeat testing. ) mice. Uk, a Red Ventures Company and Interpretations and minerals too much dietary fat,! Draw and is often high factors, including your age and status of pregnancy of bad bacteria Comprehensive panel. Blood in children and in pregnancy are very different at the values presented here by celiac disease or an amount. To draw a small sample of blood from your arm Goldman L, Garca-Unzueta M, Tenorio JA, al. On this website increase ALP levels but no underlying health problem for and! And the last trimester of pregnancy production ( Regan, Nagao isoenzymes.... Or conditions can impair ALP synthesis and lead to a drop in the blood is 20 to 140.. Low blood alkaline phosphatase roles of the previously exposed Methods and Interpretations get your patients our... Increase is higher than that for adults, especially in primary biliary cirrhosis or.! Affects bone growth or alkaline phosphatase: normal range by age the increased activity of bone there is often high open panel. 612 hours before the test requires a healthcare professional to draw a small sample of blood your... Than 2-fold the URV ) can predict transplant-free survival rates of patients with primary biliary cirrhosis, which... Obtained with different assay Methods should not to eat and avoid, when see... For any of the local population, the influence of fasting, and blood type Elsevier Saunders 2016.

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